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Home - Products - GPCR/G Protein - Hedgehog (Hh) - SAG hydrochloride (912545-86-9(free base))

SAG hydrochloride (912545-86-9(free base))

CAS No. 2095432-58-7

SAG hydrochloride (912545-86-9(free base))( —— )

Catalog No. M35280 CAS No. 2095432-58-7

SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 92 Get Quote
10MG 147 Get Quote
25MG 266 Get Quote
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Biological Information

  • Product Name
    SAG hydrochloride (912545-86-9(free base))
  • Note
    Research use only, not for human use.
  • Brief Description
    SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
  • Description
    SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Pregnant C57BL/6J mice Dosage:15, 17, 20 mg/kg Administration:A single i.p.Result:Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog/Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2095432-58-7
  • Formula Weight
    526.52
  • Molecular Formula
    C28H29Cl2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 25 mg/mL (47.48 mM; Ultrasonic) DMSO : 21.67 mg/mL (41.16 mM; Ultrasonic )
  • SMILES
    Cl.CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.?
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